First of all, I have a good sense of direction. I've been in Buffalo for 32 years starting at the Main Street Campus. When I travel on Main Street, I always have "felt" like I was moving east or west instead of north or south. Do you know what I mean? I live in the suburbs now and I don't feel disoriented at all. Transit runs north and south. Broadway runs east and west... no problem.
Main, Delaware, Elmwood "feel" like east-west roads to me.